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miércoles, 19 de diciembre de 2012

Anatomía de la violencia en USA

What’s Behind America’s Gun Violence

By Jack A. Smith


A todos nos ha sobrecogido la matanza de niños estadounidenses ocurrida en la escuela elemental Sandy Hook, Newtown, Conn. Conocemos algunos detalles: las terroríficas anécdotas que rodearon a la masacre. Pero ante hechos de semejante horror hace falta profundizar en los orígenes de la violencia y su contexto social. Y eso es lo que intenta ofrecer aquí Jack A. Smith. 

Url of this article:
http://www.globalresearch.ca/whats-behind-americas-gun-violence/5316097

There is more than the act of one individual involved in the mass gun killings that take place in America— the most recent being the massacre of 20 young children and seven school workers at the Sandy Hook Elementary School in Newtown, Conn., Dec. 14.

The main culprit, of course, is the late killer, Adam Lanza, 20.

But such events occur within a context of shared responsibility for the unparalleled number of mass and individual shooting deaths that take place in the United States every year. This includes the political system and politicians, the National Rifle Association and other gun lobbies, and federal, state and local governments. Each has played an indirect role in the latest and earlier slaughters.
Of these other responsible parties, one is our political system that refuses to strengthen absurdly deficient federal and state restrictions on the possession of various types of arms. Another is the irresponsible politicians who make it relatively easy for criminals, people with mental problems, and those who are unfit to possess weapons for other reasons to accumulate a private arsenal. In recent decades— despite the fact that last year there were over 11,000 murders by firearms in the U.S. and another 20,000 gun deaths from accidents and suicide, not to mention many more injuries — the great majority of American politicians have been too gutless to fight for tougher laws.
President Obama was moved to tears in announcing the deaths of 6- and 7- year old children in Newtown, and said he might take “meaningful action” of an undefined nature. But Obama is risk averse and has shown a disinclination to tangle with the pro-gun lobbies throughout his first term — so there’s a chance all we’ll get is tears and rhetoric even though 80% of the American people want gun owners to secure police permits, and nearly 90% would require background checks on all gun sales.
On the other hand, the fact that 20 youngsters were massacred has shocked the nation to the extent that it may be politically advantageous for the White House and Congress to pass token legislation. Most conservative Republicans will do whatever is possible to block progress on gun control, but they may be less obstructive if a proposed law is weak and limited. No major changes are anticipated.
At one time, the Democratic Presidents were willing to support gun control measures, in contrast to the recalcitrant rightists, but that’s changed in recent years. President Lyndon Johnson in the 1960s  was a strong advocate, seeking passage of national legislation demanding that firearms owners obtain licenses registering all guns and rifles. It failed. After a mass shooting in the early 1990s President Bill Clinton fought for and won two gun control laws. The Democrats were quiet during George W. Bush’s eight years and silent during the last four.
Next in responsibility for the murders is the National Rifle Association and other gun owner or industry lobbies such as the Gun Owners of America, which sports an executive director, Larry Pratt, who actually made this comment soon after the school killings: “Gun control supporters have the blood of little children on their hands. Federal and state laws combined to insure that no teacher, no administrator, no adult had a gun at the Newtown school where the children were murdered. This tragedy underscores the urgency of getting rid of gun bans in school zones.”
The well-funded and fanatically supported gun lobbies greatly influence the politicians through payoffs and the threat of uncompromising  electoral opposition. In order to fulfill its function as the propaganda instrument of the firearms owners and industry, the NRA argues disingenuously that the slightest regulation will eventually lead to banning of all guns for civilians, including those for home defense, hunting and target shooting.
A large percentage of American’s appear to believe the lobby’s extremist propaganda and oppose efforts strengthen gun laws. They seem to think a Constitutional amendment provides them the right to convert society into a modern version of the Wild West, where we can “stand our ground” with bullets even against the innocent and unarmed if we claim to have been threatened.
In this regard, writes Zack Beauchamp Dec. 14 in AlterNet: “The Second Amendment prohibits strict gun control. While the Supreme Court ruled in D.C. v. Heller that bans on handgun ownership were unconstitutional, the ruling gives the state and federal governments a great deal of latitude to regulate that gun ownership as they choose. As the U.S. Second Court of Appeals put it in a recent ruling upholding a New York regulation, ‘The state’s ability to regulate firearms and, for that matter, conduct, is qualitatively different in public than in the home. Heller reinforces this view. In striking D.C.’s handgun ban, the Court stressed that banning usable handguns in the home is a ‘policy choice‘ that is ‘off the table,’ but that a variety of other regulatory options remain available, including categorical bans on firearm possession in certain public locations.”

The federal government, too, must assume responsibility for creating a national culture of guns and violence that leads to continuing mass murders and individual killings. They averaged 30 a month last year. For every 100,000 residents, the U.S. averages five murders. In England it’s 1.2 murders; in Japan it’s 0.5.

The U.S., working with the arms industry, is the biggest seller of weapons worldwide, mostly to foreign militaries. It also entertains the greatest military arms budget in global history. And by its glorification of the military and of war Washington has contributed mightily to the sense that we are a gun-slinging people, at home as well as abroad, on Main St. USA as well as al Rasheed St. Baghdad.
America is the most violent country of all the advanced industrialized nations in the Organization for Economic Co-operation and Development. From slavery to the displacement and annihilation of the original peoples in order to seize the entire continent, to modern day wars, regime changes, and torture overseas, “violence is as American as cherry pie,” as H. Rap Brown once reminded us.
In the U.S. during the last 30 years, Mother Jones magazine informed its readers July 30, there “have been at least 62 mass murders carried out with firearms across the country, with the killings unfolding in 30 states from Massachusetts to Hawaii.” This includes 2012’s “horrific mass murder at a movie theater in Colorado on July 20, another at a Sikh temple in Wisconsin on Aug. 5, another at a manufacturer in Minneapolis on Sept. 27—and now the unthinkable nightmare at a Connecticut elementary school.”
State and local governments must assume responsibility as well for contributing toward a violent and gun-loving society. Considerable moves toward militarizing the police have taken place in recent decades as a result of the exaggerated drug wars and hyped-up terrorism wars. In the 20 years leading up to 2007 (the latest figures), special weapons and tactics teams (SWAT)  have increased 1,500 percent.
Police brutality is a frequent reality — mostly  but not exclusively in urban areas and at political, worker or popular protests and  occupations. We’ve handed our police departments a huge array of violent instruments that are, to say the least, disproportionate to most situations. Here is some of their equipment:
For elite SWAT teams in their Darth Vader uniforms: submachine guns, automatic carbines or rifles, semiautomatic combat shotguns, sniper rifles, gas, smoke and flashbang grenades. For regular police: handguns, concealable off-duty handguns, shotguns and/or semiautomatic rifles, tactical batons, nightsticks, electroshock guns (Tasers), mace pepper spray, tear-gas. beanbag shotgun rounds, body armor, and loud noise devices. Beginning to arrive: aerial surveillance drones, soon to be widespread and weaponized.
In combination — weak gun laws and a compliant political system fearful of powerful lobbies; a national history of violence, militarism, and frequent aggressive wars against smaller nations; and the gradual militarization of police— these are factors that have significantly helped create the gun culture in the United States.

It’s time to change all of this, but it’s not on the immediate horizon. Enhanced gun control, however,  has a chance over the next several years. The great majority of Americans call for expanded gun control. Today, 40% of gun owners have not even been subjected to a background check. It should be everyone. Every gun owner should also have a license from whatever authority issues them. At present, trade shows and private sellers don’t need registration or license information. This must change. And it would be good if there was one overall national law instead of different state laws.
Obviously there should be a reduction in the number of guns in the U.S. The purchase of assault weapons, and  automatics with large magazines should be banned, as should large private arsenals. There used to be a law regulating assault rifles but it expired. It was very weak with many loopholes and a new one should be much tougher. A number of people think assault rifles should be completely banned. Some gun control advocates see no need for concealed handguns at all on the streets at all, much less efforts to allow them in schools, sporting events, bars and elsewhere.
The American people are not seeking to place impossible obstacles in the way of gun ownership. They want tighter regulation and licensing. Banning all guns except for those possessed by the military and the police will never pass, and shouldn’t for a number of reasons including the fact that political systems can and do go wrong. At times, an armed citizenry is most necessary.

There are a number of good gun control groups in the U.S., such as the well-known Brady Campaign to Prevent Gun Violence, but they are small with not much clout. It time for the American people, especially the liberals, progressives and the left, to unify in action on this issue and organize mass political and electoral activism for as long as it takes to vastly reduce gun violence in America.—

 I’m sure we all agree with these lines from an editorial in the New York Times the day after the shooting in Newtown: “There is no crime greater than violence against children, no sorrow greater than that of a parent who has lost a child, especially in this horrible way.”

It is good to remember this in terms of all children, not just our own. According to the UN, a half-million children, many even younger than those at the Sandy Hook Elementary School, died as a result of Washington’s 1990-2003 sanctions against Iraq.  We don’t have the child death figures from the wars in Afghanistan an Iraq but we do have some regarding Vietnam from various online sources:

1. Ten percent of the child population of North Vietnam was killed, mainly by U.S. bombers. Another 400,000 suffered birth defects because of the U.S. Agent Orange defoliation campaign. Untold thousands continue to die to this day from accidentally detonating unexploded American land mines.

2. According to American estimates (the Pepper Report) there have been 250,000 children killed, 750,000 wounded and invalided for life in a South Vietnam of 14,000,000 inhabitants. The great majority were killed by U.S. bombers, which decimated (allied) South Vietnam in efforts to destroy the liberation army and its many millions of southern supporters. More than 10,000 sorties by B-52s of the U.S. Strategic Air Command, have been carried out over South and North Vietnam, each plane capable of dropping over 30 tons of bombs; that the number of bombs dropped monthly by American planes exceeds that dropped by U.S. planes in the European and Mediterranean theatres in the Second World War.

3. On 27 September 1967 at 7:30 a.m., the day after classes reopened following the summer recess, while the children were happily bent over their first lessons, four U.S. jets, swooping in from the sea, fired rockets and dropped four CBUS (about 2,400 pellet bombs) on the first and second degree schools of Ha Fu (Ha Trung district of Thanh Hoa province) killing 33 pupils from eight to 12 years and wounding 30 more, including two teachers.

I’m sure we all agree with these lines from an editorial in the New York Times the day after the shooting in Newtown: “There is no crime greater than violence against children, no sorrow greater than that of a parent who has lost a child, especially in this horrible way.”

It is good to remember this in terms of all children, not just our own. According to the UN, a half-million children, many even younger than those at the Sandy Hook Elementary School, died as a result of Washington’s 1990-2003 sanctions against Iraq.  We don’t have the child death figures from the wars in Afghanistan an Iraq but we do have some regarding Vietnam from various online sources:

1. Ten percent of the child population of North Vietnam was killed, mainly by U.S. bombers. Another 400,000 suffered birth defects because of the U.S. Agent Orange defoliation campaign. Untold thousands continue to die to this day from accidentally detonating unexploded American land mines.

2. According to American estimates (the Pepper Report) there have been 250,000 children killed, 750,000 wounded and invalided for life in a South Vietnam of 14,000,000 inhabitants. The great majority were killed by U.S. bombers, which decimated (allied) South Vietnam in efforts to destroy the liberation army and its many millions of southern supporters. More than 10,000 sorties by B-52s of the U.S. Strategic Air Command, have been carried out over South and North Vietnam, each plane capable of dropping over 30 tons of bombs; that the number of bombs dropped monthly by American planes exceeds that dropped by U.S. planes in the European and Mediterranean theatres in the Second World War.

3. On 27 September 1967 at 7:30 a.m., the day after classes reopened following the summer recess, while the children were happily bent over their first lessons, four U.S. jets, swooping in from the sea, fired rockets and dropped four CBUS (about 2,400 pellet bombs) on the first and second degree schools of Ha Fu (Ha Trung district of Thanh Hoa province) killing 33 pupils from eight to 12 years and wounding 30 more, including two teachers.

Remember the children — from Newtown to Vietnam!.
Copyright © 2012 Global Research

martes, 18 de diciembre de 2012

Entra en nosinjuguetes.es y colabora


Ni un niño sin juguetes: Aquí enlazo con nosinjuguetes para apoyar una iniciativa preciosa. Me dirijo especialmente a los visitantes españoles de codondesastre. A continuación va la presentación de nosinjuguetes.es.

Presentación

Campaña para recoger juguetes nuevos o usados (en buenas condiciones y limpios) para los niños en Navidad. ¡No dejes que ningún niño se quede sin juguetes! 
Esta página está creada para facilitar el envío de juguetes en estas Navidades a niños de familias que estén atravesando problemas económicos. La página permanecerá abierta hasta el 3 de enero de 2013.

Funciona de este modo: quienes necesitéis juguetes tenéis que apuntaros aquí en el botón “dar de alta para recibir regalos” y rellenar el cuestionario al completo. Y quienes podáis dar juguetes usados (en buen estado y limpios) o enviar una tarjeta regalo de una juguetería, también tenéis un botón “si quieres donar regalos” donde rellenar un simplísimo cuestionario.

Con esos datos (que borraremos el día 6 de enero) os iremos emparejando. Al donante le buscaremos una familia que necesite juguetes y viva lo más cerca posible suyo para que se los haga llegar. Para ello, al donante le enviaremos un SMS o mail con los datos de esa familia a la que hará feliz con sus juguetes. (Más información en la pestaña “información”) 

Las armas químicas y bacteriológicas del futuro

Chemtrails, Aerosol Geoengineering and Bioengineering: A Massive Biological Experiment of Unknown Purpose
By Prof. James F. Tracy


Olvídense ustedes queridos/as visitantes de codondesastre de las mandangas agoreras, las mediums, los hechiceros mayas y otros entretenimientos catastrofistas destinados a entretener al personal. El presente artículo puede parecer exagerado. Pero no lo es. James F. Perry ofrece datos que indican por dónde van los tiros. Uno puede dudar que se estén realizando experimentos masivos para poner a punto armas químicas y/o bacteriológicas. Pero de lo que no hay dudas es que los medios más poderosos contra los seres vivos son  elementos con capacidad de desorganizar su ADN. Ahora piensen lo que les de la gana. No es un expediente X.  Y la verdad no está ahí fuera.

Url of this article:
http://www.globalresearch.ca/chemtrails-aerosol-geoengineering-and-bioengineering-a-massive-biological-experiment-of-unknown-purpose/5315539

“The ultimate solution is a multiplication of leverage by citizens to the point where it simply cannot be denied”. -Clifford Carnicom
The materials disbursed in stratospheric aerosol geoengineering operations contain a combination of ionizable metallic salts, filaments, gel-type materials, and crystals. These are the longstanding and deeply interrogated observations of independent environmental research scientist Clifford Carnicom given on a December 10 conference call organized by GlobalSkywatch.com director Russ Tanner. During the meeting, coincidentally held on International Human Rights Day, Carnicom asserted that because the system of responsible government has failed, the immediate collective efforts of citizens are necessary “to claim their rights upon this planet.”[1]
His remarks were made just three months after his presentation at the Consciousness Beyond Chemtrails conference held in Los Angeles last summer. In that talk, “Geoengineering and Bioengineering: The Unmistakable Link,” Carnicom upheld his research detecting such a correlation. “’Is there a direct relationship between the alteration of living systems (us) and ecosystems (the environment)?’” he asks. “My answer is unequivocally, ‘Yes.’”
Mr. Carnicom’s work began in 1999 when he noted clear changes in the skies overhead. He has since produced a large body of sound and meticulous yet accessible research reports examining the nature and contents of such aerosols, all of which are available at carnicominstitute.org. Carnicom also oversees the Morgellons Research Group, a body of concerned citizens, health care professionals, scientific researchers and microbiologists who devote their time to investigating this unfolding syndrome.
The implications of his observations—that virtually every breathing organism is an unwitting participant in a massive biological experiment of unknown purpose—have proven terrifying enough to prevent many individuals from even tentatively considering his investigations and hypotheses. “There’s a personal journey everyone has to take about the reality of this,” Carnicom told call participants.
The most well-known manifestation of such nano-biologicals is the oft-misunderstood Morgellons ailment, an especially unusual and disturbing condition marked by painful dermal lesions through which such nano-fibers protrude. Tammy, a participant on the conference call suffering from Morgellons who became intimately informed about the sickness because of Carnicom’s work, asked if the broader population was also susceptible.
“I want to be as accurate as possible if I’m going to make a public declaration,” Carnicom stated. “The diplomatic way of saying this is that the evidence indicates that the general population is subject to the very same symptoms that Tammy is experiencing.”
How can one determine whether they are an unknowing subject of bioengineering? In 2008 Carnicom presented a simple technique developed by naturopathic physician Gwen Scott for the lay population to detect the presence of nano-fibers in their bodies. A mouthwash consisting of two teaspoons dry red wine and one teaspoon hydrogen peroxide vigorously applied for five minutes yielded observable clumps of fibrous strands comprised of an “encasing filament, sub-micron filament network, Chlamydia-like structures and the ‘hybrid form’” in fourteen subjects tested from diverse geographic locations across the US.
According to Carnicom such organisms “have now been discovered repeatedly across all major body systems and functions, including skin, blood, hair, saliva, dental(gum), digestive, ear and urinary samples.” [2]

US Government’s Conflicted Interest
Shortly after Carnicom began his research in the late 1990s major government and corporate entities with probable ties to this program made numerous repeated visits to the researcher’s website. Their interest suggests the threat Carnicom’s investigations posed in making such programs publicly known. IP addresses employed to peruse the site included offices as high as the Secretary of Defense and Air Force Headquarters, as well as over one dozen US Air Force bases, several US-based research laboratories, the Environmental Protection Agency (EPA), and the corporate offices of Lockheed, Boeing, Merck Pharmaceuticals, Arco Chemical, Kaiser Permanente, and the Mayo Clinic.[3]
Yet such curiosity fails to permeate the US agencies entrusted with the preservation of the environment and public health. Even though Carnicom is producing especially valuable research and has persistently called for regulatory intervention on the public’s behalf, the EPA and Centers for Disease Control and Prevention have been wholly dismissive of his findings and requests to actively enforce existing laws intended to protect the environment and public health. Nor have these agencies presented comparable evidence of their own refuting Carnicom’s findings and justifying their failure to act upon the standards under which they are purportedly governed.
For example, when Carnicom sent the EPA samples of fibrous pollutants for analysis several years ago the agency responded, “It is not our policy to identify unsolicited materials.” Carnicom characterized this key instance of bureaucratic denial as “a powerhouse of innuendo and obfuscation that has never been resolved. When you have a specific mission statement you do not adopt a policy that suits the person in office at the time.”
Along these lines in early 2012 the CDC announced the findings of its inquiry into Morgellons by stating that it could not identify an origin for the fibers and concluding that individuals demonstrably suffering from the condition were “delusional.” Environmental writer Randy Ananda commented that the obfuscation merely provided cover for the Department of Defense’s ongoing experimentation.[4]

The US Government and Human Experimentation
The US government and military have long possessed the capacity and demonstrated the will to violate the Nuremberg Code by using nerve, biological, and radiological agents on unsuspecting human subjects.The fluoridation of public water supplies and above-ground nuclear testing are but a few dramatic and irrefutable examples. The premeditated will to do so further resounds in the government’s overt sponsorship of over 700 Nazi scientists under Operation Paperclip. The fruits of their research included the noxious and debilitating mycoplasma stealth pathogen derived from the brucellosis bacterium that likely infects many today. (Pueden leer el artículo en la URL citada)

Further, the US military’s ability to administer lethal substances on civilian populations is well established. In 1969 testimony before the Hous

lunes, 17 de diciembre de 2012

Inflamación crónica y Alzheimer



Deciphering the mechanism underlying late-onset Alzheimer disease

by Dimitrije Krstic & Irene Knuesel  
El trabajo que he escogido tiene que ver con el desarrollo del Alzheimer, (AD)enfermedad degenerativa del sistema nervioso central caracterizada por la formación de placas amiloides. Es muy interesante por arrojar luz sobre cómo se desencadena dicho proceso en relación a distintos factores celulares. 
Pese a los ingentes esfuerzos investigadores dedicados a comprender los complejos mecanismos moleculares asociados con el origen y desarrollo del Alzheimer  todos los ensayos clínicos recientes han resultado fallidos. Según los autores del presente trabajo publicado en "Nature"  mucho tiene que ver a que se da por cierto que los mecanismos moleculares que desencadenan la enfermedad, vinculada a ciertos genes, (se sabe con seguridad que existen genes que favorecen el desarrollo de AD) son idénticos a los que ocurren cuando dicha dolencia se presenta en edad muy avanzada. Aquí se describe la importancia de los procesos inflamatorios crónicos que, estudiados en un modelo experimental, consiguen reproducir la formación placas amiloides y los cambios degenerativos. En resúmen se trata de desentrañar detalles de qué mata a las células nerviosas y cómo ocurre. Al menos en el presente estudio se apunta a la inflamación crónica como posible desencadenante a nivel molecular.
Review criteria (Para aquellos lectores que deseen hacer una revisión del asunto incluyo los criterios de búsqueda que siguieron los autores. Les serán muy útiles)
Full-text, English-language articles were included in the search, without restrictions on publication date. We searched the MEDLINE and PubMed databases, and used the Google search engine, for terms including: “Alzheimer disease”, “inflammation”, “neuroinflammation, “ageing”, “GWAS”, “infection”, “cognition”, “dementia”, “tau hyperphosphorylation”, “amyloid precursor protein”, “axonal transport”, “cytoskeleton abnormalities”, “oxidative stress”, “lysosomes”, “autophagy”, “protein degradation”, “microglia”, “senile plaques”, “neurofibrillary tangle”, “neurodegeneration”, and “caspases”. Reference lists of selected articles were searched to identify further references. Our search for observations in AD was based on selected reviews on clinical and pathophysiological aspects of AD, and on PubMed searches using the above terms in combination with: “oldest-old”, “nonagenarians”, “without/no dementia”, “high pathology”, AND the filter “species: human”.

top
"Despite tremendous investments in understanding the complex molecular mechanisms underlying Alzheimer disease (AD), recent clinical trials have failed to show efficacy. A potential problem underlying these failures is the assumption that the molecular mechanism mediating the genetically determined form of the disease is identical to the one resulting in late-onset AD. Here, we integrate experimental evidence outside the 'spotlight' of the genetic drivers of amyloid-β (Aβ) generation published during the past two decades, and present a mechanistic explanation for the pathophysiological changes that characterize late-onset AD. We propose that chronic inflammatory conditions cause dysregulation of mechanisms to clear misfolded or damaged neuronal proteins that accumulate with age, and concomitantly lead to tau-associated impairments of axonal integrity and transport. Such changes have several neuropathological consequences: focal accumulation of mitochondria, resulting in metabolic impairments; induction of axonal swelling and leakage, followed by destabilization of synaptic contacts; deposition of amyloid precursor protein in swollen neurites, and generation of aggregation-prone peptides; further tau hyperphosphorylation, ultimately resulting in neurofibrillary tangle formation and neuronal death. The proposed sequence of events provides a link between Aβ and tau-related neuropathology, and underscores the concept that degenerating neurites represent a cause rather than a consequence of Aβ accumulation in late-onset AD".
Key points
  • Despite tremendous investments in basic and clinical research, no cure or preventive treatment for Alzheimer disease (AD) exists (Para el AD no hay tratamiento preventivo o cura)
  • A re-evaluation of the current view of the mechanisms underlying late-onset AD pathology is a prerequisite for future translational approaches (La re-evaluación de los mecanismos que desencadenan el (AD) en la edad avanzada es un prerequisito para futuros desarrollos)
  • Inflammatory processes are strongly correlated with AD onset and progression in humans, and could have a pivotal role in disease aetiology (Los procesos inflamatorios se encuentran marcadamente correlacionados con el inicio y desarrollo de AD en humanos y tienen una función esencial en la etiología de la enfermedad)
  • Chronic inflammation coupled with neuronal ageing induces cellular stress and concomitant impairments in basic neuronal functions (La inflamación crónica asociada con el envejecimiento neuronal provoca estres y el concomitante fallo en las funciones celulares básicas)
  • Inflammation-induced hyperphosphorylation and missorting of tau might represent one of the earliest neuropathological changes in late-onset AD (La inflamación desencadena cambios como por ejemplo la hiperfosforilación)
  • Molecular changes underlying late-onset AD involve impairments in cytoskeleton stability and axonal transport, which could trigger axonal degeneration and formation of senile plaques and neurofibrillary tangles, resulting in neuronal death (Los cambios moleculares que se producen durante el desarrollo de (AD) en edad avanzada conllevan disfunciones del citoesqueleto, del transporte axonal y pueden favorecer la degeneración del axon y la formación de placas seniles, además de otros cambios en las neurofibrillas. Los cambios estructurales conducen a la muerte de las neuronas)
The inflammation hypothesis of late-onset Alzheimer disease.
Figure 1 : The inflammation hypothesis of late-onset Alzheimer disease. Unfortunately we are unable to provide accessible alternative text for this. If you require assistance to access this image, or to obtain a text description, please contact npg@nature.coma | During healthy ageing, a conserved protein extrusion mechanism compensates for ageing-dependent failures in protein clearance and degradation (step 1). Cellular stress to ageing neurons accelerates formation of varicosities and their extrusion into the extracellular matrix, where they are phagocytosed by surrounding glia (step 2). If aged neurons experience chronic inflammation, tau becomes hyperphosphorylated and is missorted to somatodendritic compartments, which impairs axonal transport (steps 2 and 3). 
b | Consequently, stress-induced APP accumulates in axonal compartments and in larger swellings (step 3). Chronic inflammation also 'primes' microglia to subsequent immune challenges (step 3). Blockade of axonal transport leads to synaptic destabilization or loss, and is accompanied by formation of PHFs in neurites and membrane leakage at axonal swellings (step 4). Axonal leakage exposes cellular proteins to lysosomal proteinases, promoting formation of neurotoxic peptides. Hyperreactive microglia cannot properly remove dystrophic neurites, and create a toxic proinflammatory environment that affects surrounding neurons. Senile amyloid-β plaques begin to form (step 5). In response to neuritic degeneration, caspase activation triggers formation of neurofibrillary tangles (step 6). Imbalances in excitatory–inhibitory neurotransmission and the neurotoxic proinflammatory environment initiate pathology in interconnected brain areas. Abbreviations: APP, amyloid precursor protein; PHF, paired helical filament.


    domingo, 16 de diciembre de 2012

    Murder made in USA


    
    Imagen del asesino en el año 2005.
    Nadie sabe a ciencia cierta quién era el joven pálido, alto y delgado llamado Adam Lanza. Ahora, que la tragedia embarga toda la nación estadounidense afloran las interpretaciones. Que si era un solitario. Que si no tenía amigos. Y hasta se señala como significativa su ausencia de Facebook. Pero nada de lo mencionado incuba un asesino. No hay respuesta. Lo cierto, lo único real es que un sujeto varón de 20 años se cargó a su madre, con quien se dice que solía precticar tiro. Y luego emprendió la horrible carniceria contra los pequeños, inocentes, alumnos de la escuela a la que él mismo había asistido. Los niños recibieron más de un disparo.Una clase completa pereció a su furia. Todo en unos 5 horrendos minutos.Terminó suicidándose. Y así jamás USA entenderá cómo se crían semejantes ciudadanos.
    Tal vez, además de retomar la controversia en cuanto a la posesión de armas, deberían reconocer que en Estados Unidos con frecuencia se hace apología de la violencia. Del militarismo. Se celebra la violencia patriotera y chovinista. El orgullo del matón más fuerte. Ojalá que las sentidas lágrimas de Barack Obama fructifiquen en sabiduría.