La depresión: un abrazo anticipado de la muerte.

La depresión es una enfermedad mental grave. En 1992 hice una 

revisión del asunto, y al consultar con varios psiquiatras no dudé 

de encabezar el artículo de "El País" como 

"La depresión : un abrazo anticipado de la muerte". 

Aquí "Science" se ocupa del asunto. Ofrece nuevos y 

esperanzadores datos.

INTRODUCTION

Defeating the Dementors

Considering its impact on an individual's quality of life and subsequently on the economy and society in general, gaining an understanding of what causes depression and trying to develop effective therapies is of utmost importance.

REVIEW

Synaptic Dysfunction in Depression: Potential Therapeutic Targets

R. S. Duman and G. K. Aghajanian

Depression causes neuronal atrophy and decreased synaptic connections in brain areas that control emotion, mood, and cognition.

PERSPECTIVE

Depression and Hippocampal Neurogenesis: A Road to Remission?

A. J. Eisch and D. Petrik

Adult hippocampal neurogenesis as a possible target for the treatment of depression.

PERSPECTIVE

Are We Getting Closer to Valid Translational Models for Major Depression?

O. Berton et al.

Developing appropriate animal models of depression continues to be a substantial challenge.

PERSPECTIVE

The Science of Resilience: Implications for the Prevention and Treatment of Depression

S. M. Southwick and D. S. Charney

Finding the reasons why some individuals are more protected against depression than others might improve future therapies.

RELATED REVIEW IN SCIENCE

Theory and Simulation in Neuroscience

W. Gerstner et al.

A review of the interaction of theory and simulation using examples of top-down and bottom-up studies and some current developments in the fields of computational and theoretical neuroscience.

RELATED EDITORIAL IN SCIENCE

The Burden of Mood Disorders

H.-U. Wittchen

Reducing the burdens of mood disorders requires major shifts in research, clinical practice, and public health by incorporating multidisciplinary models of intervention.